Research Page

Pharmacological Interventions

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This list contains some of the current research activities that are happening in New York State. Should you wish further information on the research project you should contact the program director. If you would like to include your research on this list contact ASAP.

Program Director Type of Grant / Project Description 

Addie Corradi
Beth Israel Medical Center
First Avenue & 16th Street
New York, NY 10003

 

CSAT Targeted Capacity Expansion/SAT Grant
The applicant’s methadone maintenance treatment program proposes to establish a comprehensive intensive day treatment program for women only. The proposed program will serve at risk ethnic minority women by responding to women’s unique needs and being culturally sensitive. On site services will include methadone maintenance, drug counseling, HIV testing and counseling, counseling for sexual abuse, domestic violence, and negotiating safer sex, and workshops on parenting, employment skills, and life skills training.
Robert Carey
Central NY Research Corporation
800 Irving Ave.
Syracuse, NY 13210
NIDA Project Interoceptive Drug Cue Conditioning of Cocaine Effects
The overall objective of this proposal is to investigate interoceptive drug cue conditioning of cocaine stimulant effects. This research is important for the identification of the ways interoceptive drug cues can activate or inactivate cocaine conditioned stimuli.
Date Started: 30-Sep-99  Date Ends: 31-Aug-03
Adam Bisaga
Columbia University Health Sciences
OGC
New York, NY 10032
NIDA Project Evaluation of NMDA Antagonist for Opiate Dependence
This application for a mentored research career award aims to enhance research skills of principal investigator by focusing on a systematic laboratory and clinical evaluation of memantine, an NMDA antagonist, for the treatment of opid dependence. Two aspects of pharmacotherapy will be addressed: detoxification and relapse prevention. This novel approach to treatment will initially evaluated using a laboratory model, and will be followed by a controlled clinical trial.
Date Started: 1-Sep-99  Date Ends: 30-Jun-04
Eric Collins
Columbia University Health Sciences
OGC
New York, NY 10032
NIDA Project Novel Treatment Strategies for Opioid Dependence
This application for a mentored clinical scientist development award aims to enhance the developing skills of Eric Collins, MD, by focusing on several approaches to testing treatment strategies for opid dependence. The research plan includes the following: a laboratory study of the effects of naltrexone on heroin self-administration; double-blind clinical trials comparing naltrexone precipitated detoxification with buprenorphine as intermediary detoxification agent for transition to naltrexone maintenance; and an open trial combining naltrexone maintenance with relapse prevention/coping  skills training.
Date Started: 31-Aug-96  Date Ends: 31-Aug-01
Maria Sullivan
Columbia University Health Sciences
OGC
New York, NY 10032
NIDA Project Opiate & Nicotine Dependence - Medications and Therapy
No further information is available at this time.
Date Started: 1-Sep-99  Date Ends: 30-Jun-04

Ernest Drucker
Montefiore Medical Center
(Bronx)
111 E 210th St
New York, NY 10467

 

NIDA Project Office Based Methadone Prescribing
Specialty methadone clinics often separate addiction treatment from primary care and reproductive health services, fragmenting medical management and marginalizing the very syndrome (addiction) that lies at the core of the problem. By developing the capacity of primary care practitioners and specialists in women’s health care to treat methadone patients within their office or health care center practice, we have the potential to foster greater integration of medical care and addiction treatment. The proposed study is a randomized clinical trial in which an office-based practitioner model for the prescription of methadone is compared to usual care in a Methadone Maintenance Treatment Program (MMTP). If successful, office-based methadone prescribing has the potential to increase the number of patients cared for and the number of clinicians skilled in addiction medicine necessary first step toward the ultimate objective of making methadone treatment more available and anticipating the changes associated with the introduction of managed care.
Date Started: 5-Sep-97  Date Ends: 31-Jul-00
Conor Farren
Mt. Sinai School of Medicine of CUNY
City University of New York
New York, NY 10029

NIAAA Project Sertraline & Naltrexone for Alcohol Dependents
The aim of this double-blind placebo controlled outpatient trial is to improve the abstinence and relapse rates in alcohol dependent subjects on naltrexone through the addition of sertraline, a seretonin reuptake inhibitor. The investigators hypothesize an increase in abstinence and a decrease in relapse in the alcohol dependent subjects through a synergistic effect of the opiate antagonistic and the serotonin reuptake inhibitor.
Date started 31-Aug-02 Date ends31-Aug-02

Marc Galanter
Nathan S. Kline Institute for
Psychiatric Research
Orangesburg, NY 10962
NIDA Project Network Therapy Development, Stage II with Buprenorphine
This is a Stage II psychosocial development study, combined with medication. It ensues from our Stage I study entitled “Development of Network Therapy for Cocaine Abuse. Only a minority of heroin addicts are enrolled in addiction treatment, and it is therefore important to develop approaches to care that will attract the larger, unserved population. Network Therapy, a comprehensive intensive, standardized, psychosocial treatment in combination with a pharmacotherapy regimen may offer one such option, and may also be appropriate for certain patients in a private medical office setting. The objective of the present study is to ascertain the relative effectiveness of Network Therapy and a less intensive level of behavioral intervention, when each is paired with an identical regimen of buprenorphine treatment.
Date Started: 1-Apr-99  Date Ends: 31-Mar-03
Suzette Evans
New York State Psychiatric Institute
1051 Riverside Dr.
New York, NY 10032

NIAAA Project Medications Development for Alcohol Abuse: NMDA Agents
Neurotransmission at NMDA receptors may contribute to many of alcohol's effects and it is postulated that modulation of NMDA neurotransmission may be effective in the treatment of alcohol use disorders. This application represents, to the grantees knowledge, the first attempt to systematically evaluate the contribution of NMDA receptor-mediated neurotransmission on alcohol's action in humans from the perspective of medication development.
Date started 30-Jun-04 Date ends30-Jun-04

Herbert Kleber
New York State Psychiatric Institute
1051 Riverside Dr.
New York, NY 10032
NIDA Project A Study of Anesthesia - Assisted Heroin Detoxification
Detoxification is and will continue to be a common first step in the treatment of individuals with heroin dependence. During the past decade, there has been considerable popular attention focused on the utilization of general anesthesia during the acute phase of antagonist-percipitated opioid withdrawal, but there have been no controlled studies of anesthesia-assisted detoxification techniques. In particular, follow-up data on patients detoxified under general anesthesia are not available. The research proposed  here aims to compare anesthesia-assisted rapid opioid detoxification (AROD) with two alternative detoxification techniques, with attention both to acute measures of withdrawal and to longer-term abstinence and compliance with naltrexone maintenance. We expect to provide information about the safety and immediate- and intermediate-term efficacy of anesthesia-assisted detoxification from heroin. We believe that this information is very important for policy makers and patients, as anesthesia-assisted detoxification techniques have proliferated in this country and throughout the world, exposing patients to the costs and risks of anesthesia, without any evidence of improved outcome for the heroin-dependent individuals who choose anesthesia as a means to detoxification.
Date Started: 5-Sep-99  Date Ends: 31-Aug-02
Frances Levin
New York State Psychiatric Institute
1051 Riverside Dr.
New York, NY 10032
NIDA Project Methylphenidate Treatment For Cocaine Abuse & ADHD
Studies targeting subgroups of cocaine abusers are needed because poor treatment outcome may, in part, be the result of comorbid psychiatric disorders. The prevalence of adult attention deficit hyperactivity disorder (ADHD) is substantially higher in treatment-seeking cocaine abusers (11%) than in the general population (1-3%). Given the comorbidity of ADHD and cocaine abuse, pharmacotherapies aimed at treating both disorders may be particularly effective. Individuals may be using cocaine to self-medicate their ADHD symptoms, due to an underlying dopamine deficit. Treating the underlying psychiatric disorder (ADHD) with methylphenidate (MPH), may result in a reduction of cocaine use, as well as a reduction in ADHD symptoms. Findings suggest that double-blind, placebo-controlled trials to evaluate the effectiveness of sustained-release of MPH is warranted.
Date Started: 20-Apr-98  Date Ends: 31-Mar-03
Bruce Dudek
SUNY at Albany
1400 Washington Ave
Albany, NY 12222
NIDA Project Pharmacogenetic Approaches to Cocaine Neuropharmacology
While there is a substantial body of evidence that individual differences in response to cocaine are mediated, in part by genetic, no single gene has been identified that can account for differential responsivity to cocaine. Recent studies in our laboratory may have moved us closer to the identification of gene(s) underlying a number of cocaine’s actions. The proposed studies will contribute to the identification of risk factors for cocaine addiction and the development of preventative and therapeutic intervention strategies.
Date Started: 1-Aug-97  Date Ends: 31-May-00

 

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| Adolescent | Behavioral Treatment Strategies | Drug Abuse/Behavior | Families
HIV/AIDS/Hepatitis C/TB
Homeless | Co-Occurring/Pharmacological Intervention |
| Outcome | Pharmacological Interventions | Women | PIC Homepage |


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 Alcoholism & Substance Abuse Providers of New York State (ASAP) 
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